	   SnapGene      ÌGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCaccaattatcactttggtcctttgcccttccaaaaatatactggtataaatgtttttaggttttggatgtcttctgactaaaatggcaactcaactttaaggtctttgcacactgagccttgcattcctttcctgctcactcctgctaacggctgctctgactttattgcactactgtactttacagcgagcagtgcaatagtattgtcaaagcatccgcgagcaggttgcacacctttcctggttcttgtcttacatcttcagtatttgtgaaaaggtttctataactttcagtgtggaaaactgtataattttgttactatgtatattttttagaaagtcatcatttgaaaaaatatcattaaattaacatttatcatttctgtatggcactgaCTCGAGTCTAGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCatgaccgagtacaagcccacggtgcgcctcgccacccgcgacgacgtcccccgggccgtacgcaccctcgccgccgcgttcgccgactaccccgccacgcgccacaccgtcgacccggaccgccacatcgagcgggtcaccgagctgcaagaactcttcctcacgcgcgtcgggctcgacatcggcaaggtgtgggtcgcggacgacggcgccgcggtggcggtctggaccacgccggagagcgtcgaagcgggggcggtgttcgccgagatcggcccgcgcatggccgagttgagcggttcccggctggccgcgcagcaacagatggaaggcctcctggcgccgcaccggcccaaggagcccgcgtggttcctggccaccgtcggcgtctcgcccgaccaccagggcaagggtctgggcagcgccgtcgtgctccccggagtggaggcggccgagcgcgccggggtgcccgccttcctggagacctccgcgccccgcaacctccccttctacgagcggctcggcttcaccgtcaccgccgacgtcgaggtgcccgaaggaccgcgcacctggtgcatgacccgcaagcccggtgcctgaGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGT  1™                                                                     
   
                  
                                                                  "                        '            '                                                                  6                                                                                                      	                                                                              
                                                                           +   #            %                                                                  
   
         	                  3                                                                                  $                            4                           "          (         ñ yÊËÌÑÖåæ5>?ãä‹
Œ
^òt’ÿ�2n€ yzœ¸úNçð´V	êWuÒ ‚W'Æ1þ² – ò �ÍÒ@iñ#
Q
*_ó“3ØF� · `æ×6å6Ä	;
�
$0CÇ+‡o C “�ûOè_-	9	W	|
ô
FKo‚(³ ®y ñ'‡ÿ^Ö
J|Ó�²8€µCƒÇ`çÿ f{Åë	µl	~	„	cvƒe>Xs2Y­ z¹Üu
X
r
¾ëX �D÷}ºÎÓjo$Y¤	L
g
‘
`´Ëß”	¯XnèÙ $žåês¯ASh¢ø7M”Áâ — Lm¿fw™rò*JÍ¹
ÿ
ô?­ò	pè4i¨G‚ F ó þ”éž
R
m
+>>µ4_»˜v œ açî$Xf_
j
Ž
â
N3LeË+ˆUD&p o ®õR©Ù	Øÿ.vG
%1*ÐÚ®ë t 40\7Êæ"jå0	B	<
À
•šD_FÙÈ|,a$ ¸ +ì7Å		<	Å	¡
¬
Ä
Ú
í
Qô¢­¿q8ˆ“ D üžé" 		+	.	:	‚	L²KØ) Px	}
›
peQ�´ M ”žµ`–	°
Gƒža¼±ÏGë X y÷AaØ	X	


µ
õ
U‘æ-w¢OšêGŒÜU ˆ zò2z#	†
×
»}9�i†¥”„“È‰è9 8”¯Ôâ¡(_ù;SÔŽ¶
Hasp–
 ‹ ò Kï{ e
  ,ˆ&
’³Ô‰DI  ° GÆ
'	Ó
d×› ½ gC„$f"I3Z Ï |ìø«¶¿Ý &?ÿYgh €0m	r	…	�
gwË&t€é>P~€‘µ®¶¾ Q]†Ùâ“ÝGY·	º	Y
\
¬
Yçú9¤ª
 } É Ýõz	A
À
 Ö {rºCÐ$:véä	ì0	ä y 8CRs�’	ÿ	
s
r¿Òþ!UæS ‘dø¬ÏÔmp4sý\O
h
ý
Ið
†loA–
 E’%)	Q ˜ÖâéÚ < > »ñª»kZM
’
O‡°Ìš R F>h~þ¥	=aµÌà•ÞDÎY?]T©› O ë·S1&	Ÿ²RÂãÕ å %mŸæÊ6‰i¸ù8³ÑŒÓž + `–½-°NŒ¶ÈB5}^	T£NŽ•© 
i 	 ³ ²Ë#Vót5˜	É	í @ Æ gHV\²
@í·Å¾ÀòõZ‚�Œ " ˜ Û ÀsÎ®Yq¬RÄàIjœ©H Ÿ Mn ¤c¸Àš#YK‰	PšóH
Î.éñ—çÒ û dxÃó+h}ÎÝ	”
º
 õ…BP«¹Ýc÷Ø5g—ƒ G Çü	8
S
ƒ
:¯ÏÛ?¶§ ô T‰Ü3–SØ½ÔN–
£?`…Çù) …ÿÉê~±Ÿn
,5¼îµN •Œbc£½	÷m	™w Jkè%Vdg
V
e
k
‰
�
·
O“èrýJQfVægW V ® ?_ðµ	MIçOEq � Ä bïa}Û	6
�
û
4µÃÌ,„'Ð" T ¤ LYbx’š§	ò	4
`
¦
È
ã
5WYyÃpºû8F‰í›Žë<ˆ ¯ S	CcÙüz+/swýÊ
2¡Š+.Dùü�—¯F Z p àÚHá9R�šI	"
H
Í
&€×ºœ§ÑõDqží_Þìö  „ öþY§¬ [>B†ŠŽ	¨
ÎÀ×å€çì·½<   ªð-j
Í	è
ÅÐÛ²«Š J ¦ 5Y-2Úæ
Á
`Eä5GÈœÄÉê¢ßA‰ e 9]…	)¤[}Ëþ 8 u ‘ © )1o©Ë 1	C	Z	›E¤/Ç!^‹Í-%Ú'  1 {8 Ùç#kP	=
?–`¼):ZÚý<H–½�Å<Zb/nV  Ç¼			Æ	Õ	Ø	á	b
y
˜
­
Å
å
7R[©/\yÀ[€‰Ã”ó ' ¹ rÆKO€Ž¾8®	í	ô		
àõ£®$1¨|ÜøÌ>� 0ñù5@jÆ		=	©	Û
gâ2Ž—qïrª' ,<J¦ÏíýÕœ]N”œ>R¨´½ÉÓÞž	¢
î
÷
c{·ÛŒÃßâ9" • xMä=ð"³#)€V*†ýE ŸÛê,	}	ƒ	ó
½Œ±=r~æ E ý¾èe˜|¹XK
³>¡´L n s › íþ#!-iu		/	;	A	Ù
Md¡¬¾Ø*TÙCê ÿw	~
,F`»Î Š Ó+1y"	%
z‘…ˆ	’ˆHo ¼ œ
Ò
#þfgÖ�µ QôFy	qR Q ºE©ý3r(	H†Ÿk@Õ>•™Sš  * N ä l•±Ê"UM‹¶4|%	—	�¨²ÐÔ‹ì ! Ú ú ŸGÍ±
„ìªb«½–Ã×ßæH�– 2„×aMb•¢Î´ø j`>Ua|‘™
€
ˆ
¶
4V’çoPƒHåæ�fÏV Y BXbàû*=Qr…™Ì
¹¿Ö›¦ë-Cøûp±E¼Ý; d Xnz1ØÙ	O	Y	
£(.D£ãY;•ÃÄÊ.m & ø4N�	ö
Úx�á0§{ m r ç—{ã²J
Ø
ò
(¼=c «½Uq…B}éü ‰ ó*v	$
�"‡ºÕ ¹ÉƒÖ3a{$	…j•§”ÓŠŽ÷R™ % c WmW`×<„N	œ	‡
Ù¸Õ~Œ:‚Â¦÷Ée: V–Õ);`ƒM	<·Ô„‹b�Ÿª¼!¹p¦dQû˜6 \ ¯Â¤¥Ô•°ãäå™ÑÒÓåæK	L	ž©º»óô·¸InoŽ�abcPbtàáîøùúqr— ] 'è°Ãâ9¦´Õæðš¢ÞÔçú³ÇÐTõ‰�œïs{ ¡g±'‚ûÕÓ×Jµvcuâw (ZŒßé]™ÄãµÖ›Õûª›ì‘ÊFðf á Wu>§Jç–øo´¼Ñksã,60t| ^ € ë :ˆºñ£èó÷I‘íÈUf±Š¼»  Œ ç ±ßL8ð|ö�¡Ñ @oµíø‡Eï;d j Ìõ‰ŒâÏ
p“:ŠÔãx ¢ÏhÜá¢²ƒ®Ã'
•ü§ûvK¶ Jv± !(-“Tœ‚Ö´ÕØwó  
)�êB^šä×(ãª
Ô
«<"¦¬Æ † [àœÖ€	�	Ðü9eœíc’¯GNS ± bÅ¶ÇÆ–PXœg  ÄûH7@ˆû}ËÊØñ  â ÿ jvhKKùDp ½BÖ“ÿäC} X² ¸—°¨µÒ‚…t¹4u ¾ Â¨Êè`	«­1_ À ?ªsl%g#J-7 [ � Ì Ó NƒÖ�Ú*P¤®íÊžV²½û]6K Ð Þ ì ÷ ø/<;‰íò]ôJ’®é@ h‹¹3 _ ˜}Ž»ÌÞøÿù¬·ÀÞéî÷f	!ÉÙ�Zòi>akŽ  ÀÅ£ø×	'çg*¼ü 65©à;†	
D
ž
Mñ÷ÿ!¯ è ¶¿Z²ŒÛêü1s	Â9V}îkžÒm?ŸZB  - � '…R™DŒn	x	¥—'u¢áê4�¶¿· �[D¸b	h\tôÌ�û¦°QÏ’¿ µ ï "œãw¶õH¢	]
nz0%/« AA¸	Z
�uèÒF < R^‡Ú+”Á/Zf»	­Pðe¥ Â pÍÞJvîË	ð	2
w
Zùˆûš:X <Þ{	Ð
x;^‹Áä  h k ~ ÍöŠãš	±ÅÎdnñÕy Ê ´%Xƒö
B
q¬”LA]Œ	 òlˆ�÷	l€ £&-¬ô2³;‰„âÀ-'4´Äå² × HÑ/Ãêå	üw‚ |ª»i�â%7£Š–·¡KÆ  sÐDÝƒw�¯Ä(
íý¨1^L
¢ïw¥" z 9v‚“	ù	

ê

 ¦Àÿ,µbçÜL^9† ?¬….U�t
 'ÙÇ1xôÌ 	n
sƒÇ"×i¯{Ý  D‹"S)t”±	Ï	è	 
Ó�VÖT¡­ Ž_›åùÉÐÕï45P
/ñB‘Æ× B ’eÄ­x^t†þ]8	q
Õ
Jnb�7B_ Cr“®vnq)Ìþ
Ê¬ñ=6m“Àá^º—§çÇ *3­ëôQ¨/[Øäi
«
Ã
á
2Ê‡)p7#’­ L ö�´!×	*	�	´
å�¡™d°×ê ŽÛT ‡ “á:Rîh¤“8d  Î F/&BªÜq	fÊ%HO´ x È Õ 7P\…Øáq’ÜÏ#r€Xè‘	Ñý/æ8¿ã£ ; = ‘«=lü[N
ïNP—ËÍ\á ² ¼ò4µÇR]	ˆž±Q	�h ? c£·¿UX|“
™GXOð¿ôY›‹ ÆÈR}‹°¼öÚlí„ÆM S £ I¦	´¹7IEìšê ƒ ïý,Gi¦8A€‰üH	!
Í äæÏôC�^¶ª  0 7 � ¨ (
ÿ>~ÇZ¡Ì@ýÙU  ¥Åü›?J\i�»	b¶á–ÂßZÂ÷Ë!òœ ” š wìL½¸<ï!@	× ³S~
 ÒE+„~Ín   P Ù ã ù k1LFü2qL”¡'	ë Öå  i_úT˜¾'C”BÃälD $ b læ_±TÒ�Ô & çf³Óï&˜ÝÐ¶ÓƒŠ¹ ˆ�›¥´uOv à æ Y=¹•nöì©7š°ëjÐ»âº5 nË¡ôáì­Â¦†ú9uŸ 	aÃúÅ6~ú8O®!«Å ¿ J©±Ÿ·É¯_	§ª¬ Ò Ý —Õ.;)O�ËÄ¢Éö	��ñ¸25J`j , ¾4‹éûC˜a	[Us¤óþ –jàl¥žA ´ Á î !›Ì*ô@uÊ	Žtmy/$. 
 g ³$W;‚‡™	°] K\ ,«16ÂÃîÅ! >uç	&ah®Æ0K8… A ¬P§q’Ãî]Ë7	A1’¿]¹‘^ w Ç Í Ô O„×p‘ÛàqW©³
gÉ$�7c : ¢Q|�¾W¯{\	˜îõWï¾ó[ƒL ‚ ¢ šîü+hI[¥ŒºG	Ÿ³¸ÆóÁéöü  “ ™ ø 0¼Ñîû K“Akm # a ß <ekåîó%^mÏàëõ¯êS‡ŒšÏºáN Ñ Ü ù3Š(ú®õùœ¦Zròik¤�ª4@I í  š=+:�Át¯`­Å/JÂ„Ä ¡ Oo¡¦‘™Âí�½ßZV¨¹6	F	ô‘îò#\èb ` ™d»ä'9Ðù$íúl­ßêôø›†™j£MÃ?l+   N¥¹ºÁ¼ÍÎÏLM§¸ïðñòó3	4	5	E	g	QÚÛÜÝÏÐêëìí*[…˜ÜÂ*+# ~~½q›¥ �¥«¸ÍNÁh	Š	"RÊÞIÉÑ/t�+óÝÈÓ,� « ¦ÄOÂi	‹	Þ	•
ö#G‰C|¬º²ôÙsk˜ ü ˆ¦,�ËßÞxø'+¹É- ÌyœCÁÆ¬¹i¤ùØ‹5†èuŽd,½ÞýhÔ% e¾ rm‘¯´Îô~Ï	,
»
j(SJhÊ#Ò0Q6&„� }áœÃj	9
E
Ÿ
˜HÐò<D}­³tl° 68ý	
?
„
°÷$ø™¨ È‡	;NÜ@B· õ€§ H ¬ 7ª§¼Å<PŒ	¬	Ó	ß	T
–
Š'3»"Ú  ‰§2	O—W~¨ß>Óän,†ºC é UŠ·Ý[—³ßTÕ‘G�t	`ÿlŸ@ñ*{. õ ý À4ÙÜëý¾{ÿ:@‘aù(¤ÈúX[Q uF�-
0
ž¤ÃÌàbª¾+\ï˜Ny\ Ê   . Ž Í!S²Çú		o	o
-ï˜Ÿ6½ë5ßþÕ ( �DÂ:Û Œ6é%-£ï¶ Êëz†­jy¥*
‡
eÇ(vÀi‚·À$  †ºšE�ÙyJv�¦â¾yO¸ Ò\õ±ÆÐÛvT]ÜRnõÍ§1{Ð… €€ˆ¿‚¡c	c	)løiËuÓ¿
üd­±“ –sn�’¢µ-
Þ
kiK$L ‚špx' 3 fb…E°Ïé%dm¤¹R	¾	¼
A†1>x7R‘ºÀ ¶ ð x·hâU	Ã	
:
Š
]éVsÑþ~1&Å0m± ~&k	
W
{
EI{d´‚X¬ #�äKléöI�£	f
l
�
¸
Þ=Rgo®÷Wç3hu WeÉÄF
^
 
¿
ì
P”™^óEK{Ï`% W x@`	•	

š
¯
T�±vNéJP‹F
 7ñ…
ºøÓGr•
 ¯ ÷¾%è!=}š½ | BB9¶	¹	ã	þ	@
[
«	 ùTå	© cðg~ü
<ÝC…	¨	 _,É0È	5·Ò ž Å b"Â[gˆ	Ü	O¶AÄÍ-¸ÜQöñ�fÑ SˆÛ•Ó¼	û	7
‚
9¢®(¦ U ­ Ã ^Kcwï´	Ú	ñ	3
5
U
d
¥
Ç
ú
XxÂqúüÂN;‡  ß«Zy�	Ì	§
É
ç
ÄÖ‰�ì–õ‰ I ¥ 8,„Ÿ¨_»Æ (49üG]Š›¼éœÞ;Yˆ3 /;IqÎðÔM“›½Æ=Q§³¼ÈÒÝ	¨	­	Ô	×	à	ì	ó	
a
x
—
ä
6Zfz¨.1[‹Þpî#©Û= dÚý ,Wht|	"‹°)<åD » 
0xþ!	Ñ
yE_ýf‘‡G  ) ° !TDŠ¨
ÌÍ©Œª?ÂÔ=³Þ˜• =3Mß0{�)Pq˜Ë
3n¢âX¥à,/úåoz~-°»Î l q ¸È‚VâÖu	›	#
I
ñ
'Ø ÁöAö| [ ®Áá£U�ä:‚J	²ÆÏúa�¨òÒÖm`ßí÷z   ê Vt‹Þ\˜‡I÷H�»e ÉEr+/ i ?´ÎÛà‹’S›Î
�”o÷Ÿî:ò° … A?‡â�	©
Ï|;•bMW¥ÉR  þ iÁŸAr�Õ’þ¸B^ Ë ö M‚÷�ÙÿÝì÷þ­¿\Öe	Øæ­èú)û\=� µ&5YZ„ÚQ¨:C‹·
C
Á íú3¯ÎY¾ vIÀ.e¡	ï	1
v
™ÑOW ñkö	
ÄÍckm«wð@‹  ©%GŽó.‚ˆ‰Žá¿,]&3�¡³¤ Š«„m	°	Î	ø	
é
	Ÿ¥Æ+�ÛzÜ]¬ËŸ  2ó.Z­uwÈ3…p
Â
à
.mÉða€�É6Å(5à6æÖ  K 6Îõ".³ AÛç	p	ä.å£7¾ÿ³¢ 3´<TŠQûFMÙNk�ÊìÅàŠ  / 6 � § ¤'		 
ãÁå6HYë™ Bœµ Ø ^E;—?	ê&*ƒ}Ì Ò”Ü¬Áë™¥t¤ Ô:IžÄÃ—¡È	7ýßð·Ä f )0†æ	�\x~.ÿ 9 v «pû{p‹z[	—0fÈ¸ ’ *2j€¥_ñÎ.Áƒ$ }¼�˜ãì&8p¤�¤ª·ÌìUk¦2	D	ÈsŒ")„¢ÛLÁÇ) ª ŸË‡Bl®³+
iŠœ4Fˆ"{±w&rj¸% |7»›«	Ò	>
—&2;A¦   tEÞ�FŽ/
zþa©½*[_þ�—§=Mã[£ðWzP    9Úx		)
î$IžÆ¿x# 2 ‡Ña„¡è$l°ÅÚQ	Ý
@u…kÛ=Kw¾c¬0oz¹ ÈT	Â	
z
¾
ë
D\ÝU]zcöÎ_�Ä2$ { wö½	”	â	
™
®
Sª¹ SäŠ|”¼ !fÒÇ	ú	8¡¶ÛÑ4  .:HïÓ]+ƒž¦²»ÇÑÜ
	³	Ö	Ù	ë	
c
¤
Æ
æ
ù
ew~§ÁÕ-0^ÅÁÝ\oèÝM¨•:‡ô† ( º ÿL/�(VgpË 	!mÌá¤¯(©<ey}²Ý”Í >sÇ�­ÀU†¢€ð
“ùöÀÈ9õ¯ Lh�@ŽØP9ž¶Õád	Ôý2®ùVÍ ¨‰$ƒ�‡H¿d 	¯	î	õ	

u
*Žjv%2ÚV?£ž 5 1òtvP@ß
lÈãL�Øä5MXj›¡ Ó“––Ç«À>	˜s|ÞÃ 
—žúoAkoŽ£²¶ëTh‰3rzð°!ƒq( 6`		ª	Ñ	.
Ü
t„j#%@«y" -Gî *e�Ñ¥ºS	²	Á	ê	
£
½
ø
Cd}¸ÔÜÄÚã#“»  =Kg§þ�×#T†G'foµÊÔàŸ	ï
�’;U8U¢® 4 Ò�_uO•±ê?S•ª¿Ð	ˆã4?WyÂ( EFÐÑŒÖ^cdFÐ&en©¾ß¿	À	é	B|‡‘àáâ23×ØÙ:ST’Á  ,Æ  ›GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                                       (                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                                                                                                                                                   "               	                              
                        
                  
                                    4            "                  _   H         M   I               H                                                                                                                                                                            (                                                                                                                                                                                                                                                                                                                                                                                                      
                                                                     "     	          
        
      
            4    "      _ H   M I     H   eY  fC  fW  f  ií  mé  tMYú.Æ]O•Ü£
ë
!Bmö¤¶\s	/w_) /·	òa`2¡æ,¦íb
å
€ 	æ		_ô
9�Å� ,¦ÆíJbð?Y[… ¾9�´			ž	Ø	4
b
�
Á
å
î
RÅÎŽºQÃü€\	Syµ		ym	A¥ß
gß
¯ÿ
&
D`�ô
¢r	®Çºc#¦ã‘ 

UÇlm	}j	o	{tµkTk®¦;	Ù
Q†Ù“º	¬¤ü	§êcsì©s}_
â
`´ß”Úž^
µ
‘æOUïd«
Ã
Pó’] çÇ£‡¸Q†Ù“º	_
â
¬
Y&¤jÂ ”× y=ÎT©ÉÎ©ÉS	Á	Þ ;ô®é¹>	ö]aµÎ©Éy6å;
õ
A¦_
â
òÉ >†BeY/q	þÊ;IQ�\ÿ‘™_
â
4ˆµ©s}æò"j_
¹
â
ô
ÿ
`´ß”²ÙÚ8a4‚m€kcþz}PpQ*.@ufá	>	S	 	À	Á	c
ð
!B\�4þåbõ1DúÇê
\^W+	P'o2ÄP=å}È	@á¬ y6å;
õ
=aµÎT©ÉaQ”@á>	ð
)
#V ,íY]?_Kü ŽœÇ+>s†¢
Á
÷
Wc×\ÃàM£Èõ|@á 	c
 >†”*l	vs�µ® 5¨:C—%á¿³S	Á	c
d$†™M$Ò±ÆÐÛÜn§ym€£‡kc¸)q,ú @ˆÁÆ ü	§mÆ Ÿñ+bsü	Î³©§É¬ 	t	o
Ð}eÇadQ°º Â R
@ \Ç\+0c
âèÝ‡	˜
­
R‰—0âü	§jþz0y ’	þœ<t ±"U4—	ì[qÌ¬§l	„	vs­€gË€P‘¾àg-7c1òtvVgß
!lÈ�¯(5…NPx	pQ¦ z
Ê
2¡ä5Gê+.ùA¯· +ì”6Ä	
r
¡
í
¾8‡˜vS	T	Á	Â	
½
C\ÜUÄ#D$èÙ
ž¤y\Ê”
r
¾˜vzÊ
2¡+.ù¯¦ 
ä5GêAP9¶2®Í'Ó
]
zÆ	7 ¦ Vdz		Õ	Ø	
b
Å
Ê
å
2O“/¡ä5GJÀ[ê+.ùA”¯ó1òtvVgS	T	Á	Â	
½
ß
!C\lÈÜU�¯(5Ä#Y§BŠÀì½ G
×-¬„'4å( ÿËÌ©<²Ý”Å	~	cZ·ú¯Î §=ãK õ³ 	äÿy¸êWc£½	"œãõ2³;‰H¢	ù	
 nµ‹ÁÄ K ’ õ³ 	ä§=ãÿD¨?Ô=˜%óˆá¿,&3³Ý
Yú96
�
'-Gî*�¥º²	ê	£
ø
d}ÔÄg
‰
èrý‹ rC`vì&Kï0{	¶	¹	û	7
[
‚
9«®	ù¦© }Í!²õ	j	o	HR³6½{†þžAk²h‰3z°qz×
»„è1  ç#kP	?Ú<½b/nW	ô
mÊÀs
£®ù8¬ÄIâžˆ ò†Ê†­*
‡vi·$`rCvì0	
£â‹ &Kï{ Vd		Õ	Ø	b
Å
å
O“/JÀ[”ó%óD¨ˆá¿,&3?Ô=˜³† 9í’ü ø'«ÐU ­ Ã ^Kcwï´	Ú	ñ	3
5
U
d
¥
Ç
ú
XxÂqúüÂN;‡ .:HïÓ]+ƒž¦²»ÇÑÜ
	³	Ö	Ù	ë	
c
¤
Æ
æ
ù
ew~§ÁÕ-0^ÅÁÝ\oèÝM¨•:‡ô†Jkè%Vdg
V
e
k
‰
�
·
O“èrýJQfVægW	 ³ ²Ë#Vót5˜	É	íd Xnz1ØÙ	O	Y	
£(.D£ãY;•ÃÄÊ.mT ¤ LYbx’š§	ò	4
`
¦
È
ã
5WYyÃpºû8F‰í›Žë<ˆØ ^E;—?	ê&*ƒ}Ì€0m	r	…	�
gwË&t€é>P~€‘µ®¶¾¸ +ì7Å		<	Å	¡
¬
Ä
Ú
í
Qô¢­¿q8ˆ“ÈT	Â	
z
¾
ë
D\ÝU]zcöÎ_�Ä2$… A?‡â�	©
Ï|;•bMW¥ÉR& d t ¸ +4ì0X\nzø4N17ÊØæ7ÅÙ"jå			0	<	B	O	Y	�	Å	
<
¡
¬
À
Ä
Ú
í
ö
Q•šÚD_£(.Dx�£ãôFY¢­¿Ù;•ÃÈá0q|§Ä,8a{ˆÊ$.m“ … ¿ þ 	aiÁÃúAJ©±Ÿ·ÅÉ¯6?~‡Ÿâú_	�	©
Ï8|§;Ar�•Õ’Obª¬®þ!MW¥«¸ÉBR^ÅR^‡Ú+”Á/Zf»	­Pðe¥ƒ ïý,Gi¦8A€‰üH	!
Í äæÏôC�^¶ªÊ( 5 º 1òÿtLv/P�È@(VgpË 	T	Â	
z
¾
ß
ë
!D\lÈÝãU]mLz�ÌØá¤¯ä(5MXcjö©Î<_ey}�›²ÄÝ2$”Í¡2ó.Z­duwÈÚý3È… ,WhtT	|	Â	
p
z
¾
Â
à
ë
".D\mÉÝðU]a€z�‹°É)6cÅö(5<Îà6_�Ä2æ$ÖåD^ € ë :ˆºñ£èó÷I‘íÈUf±Š¼»6`		ª	Ñ	.
Ü
t„j#%@«yD üžé" 		+	.	:	‚	L²KØ)# a ß <ekåîó%^mÏàëõ¯êS‡ŒšÏºáNE d R^‡Ú	+”ýXnz¾èen˜|¹1ÁØ
/ZfÙX	O	Y	»	
K
sƒ­³Ç>£"(.D£×ãY;i•¡´ÃL¯ÄP{ÝÊð.me ¥68ý	
?
„
°÷$ø™¨  ë     üý7zXZ  æÖ´F !   t/å£à	»] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*jÀÎBJ„†–ÐAÝ>¡f"ôÞAv›«ƒ�Ó’©·p”ôâ&sà{3ÌT¾h$Ž¤¾hâ|=¡ÿÌß27­|r6�
Í½;29Á´SçNÙøx*Âèƒmíœq½:œðÕM‘Ò�-Œ©76)_g®†+úTSøõT…~À6nœÃá]JÔHbG>Ý8½^œ˜ßø
d²1Âwrî/‡!÷7C±ÅÂ¶Šö.B:õj'c*Èd—°¨I±1*¨gîÜ¸mVs$�æ'ÆY97›C'yÔÌ`³r?çAœ_E÷ü›tõž|Ôqaf†þs‰a�hø‡ß…°…ªé\G‰'::rÉVÓ!éJšxÕWÿ4¶+Ê5Ö€)Bîó¼ ×Û_oº´�žØ-î’{@ÑƒxâR™ÿ-Ùè6‰­µ§‡™5où7)¸5\º�ÿQ84ÀÝN‚L°-î"`“*Õ³3Ï±•FR"—üƒùO§M8êâsUÛ½51í.Aõlùú`¦µðT/PYŽïÒÒQãá¨   ÿrƒ$Å¸ö ×Š  }…9±Ägû    YZ   (          2          2y/H‚®4fôÝ Ã  ´ý7zXZ  æÖ´F !   t/å£à t]  /oA¥ôÑ úÚb8ä�òÊééN±œÍ8¿Š'qùÎ6hjH±Ž•M¤ÍWE®OÔ×àl�@HT»³Ò§òè'TT%fÎ_ðÎ°];ñÉÚ¢ô©gš·'nMCVñk"ðiò9¦ïäª…´kB‘p0W£¥�Õ½“G(z=¬´]£AÚ.~;P¬žôu`}² óë#Mçè�ÓY)>ÿ%Çfƒ
D[0FˆkÀ{8+‘=þVÀNÉäd¦ö'[«D»Ð–åD½/[d=P½qÇèÞ:ñ·ª`§›:Œ£®­míEA:Ý‘¾PÕf§»ždRÓXJg{ÌáþAžÇ¥F(Þé]àíÒÙäwÃéƒºNrúÌ> ø„ŒÂi€µ¹",ÖYð&Ûö£â ïiž¡84"â j£3ú· W\µÒþûQ$œ*»ž†,ƒýºªcz:"DÛI²r!õ*�æƒõ)býÈÒôù÷—i0a™R,Ì¼&ù_åèåÔB–¶w2yËð)¥Y1D�ÛñºùÃ`£ÖPé±Mñ‚f¬aßˆô¦>ð—æ€Æƒ~Ìäg�Ù“ò�j¸çþOª­£€d‰É:HØ:æ aÞ¸9¸�Ðp™—m¥¢C‹nÁ�ÐØø6Â¶�õ‚x ÚÁ~ýŸa“ú¢7
»FÛ˜RN¹õo g§ª1_3	Dq�¶{p—í±,Ô×ùuÖËþÕvã´NFK¢ed¦;ûpý­£Q«ÁºÂ­ÎEqdNj‡+¬‚@ãã2Ó 4òiŸp‹%–°&iÿž¼®*–õ“ÃŒ@<QT6ñ½Ò¿y—:v½ÜŠ@–J‘|„Äœð/(6îX?MŽwæ¼Î¼'÷¿º¯cØÚ8³ÈÜ‹JH@ùÚÒ�à‚*­4=—ßAã‘4ŠäÜ`<Ñ 'áÜÇ™è�Üeƒÿ8´òÚnL«I%I+B xß›º†Ü�`~üø¼B½d\Ø2ÊÎÚ”TèT(@u  ¿�;PU-™s»«3í,Lô¾bT‚ù{2rÇ­båh¡‹K¦´º1À’†Â—ì/m_ŽÒÓg¦ØTÏðÇö4Té2eMt‰�ë“Ú…¸v³>¾À�cï¤p”ùïÄ›OXèòFÃ)H*!< ¬z0¡ý—u5T ?nþéuëŒµyÝ!ó_„EÝJLø—]‘;)ça$GÀ¤GE!´éÔ˜H[:\o÷ë¥ÖxpÌs"R½¹8neºÅÜMèr…Óºëç>™j»›ZöÈqji&í	$i»7æfã/õ€²¶ê¥±Ðþv°öfñ}š•¼TI?%ƒH|ø8‡?í'xUu¬F�Î×lù¾�èH�“–XnÉ…;yQ¹º¥=‰�ú�–ÆWuNuâk•‰eÎŠ†u1’Ìp¦×9÷x6t-žh#¹�‰o«Âø�>RÖ!GÔÔ’”A,4,,ïIF¼ýÏoY’Ü{T( ydýJgo÷Ÿ–\Ð%g›íÐª[)ùŠ.¹ý–�b|¾:¬è¹1Oyly"Ø÷›®Úa=––h‡2rû°ã‚(4x–u”B#c�0Ýk|ÿÕÅYs†‹ÃÃA®þÝo·	‡¯¥‹~S›²åÍ×¿ˆ3%>|òè¶r¤”áŸHáú¦Ø_±+�8g&×Ð°·Œ’<Qf«%F#Šæ=ÙZ]ç?òüŠafcië=rqÌVZÈÏ¬ó@“Nã†7É:3‘ª$k˜E¥Ä] |<Î Ãê8ôYµÈ‡™g†q7ý	µ0ÛîA>ôíMæŠû­ýö‹i4ÎTz±Ñ–õè!šôkÎÔl=Ë!Hã?@orP»56Æ©Cf¾nYž½Ö °7åz³*Ž4|w´ã)*?QWúv)õ±Àrvµ7
à­qsB+±?¢ÙKÌn[§6lù|-Ð@ÏìK<¢²9êÅ4PÏ²!‘ùs®ÏYˆÏ;¬K
,l�.Èž:«9Ælg+}i [Üë¬ÅGÓ5¨¾c-©ÿÌŒ[¥É Ž]Çš3Ï+ó•·.“ý³d³Èƒ´�vñFÌ·=€‚›ý…À«Á=ÿ6v;­Aa§IÀäiŸ…bNŠ§õVÕ‘é˜llËùHø
­ä*œ’·ÄOØ  lf%;TÓü"9qFª.Ò5Ë)$çœ …D2Ã¾¿Ix›�!6¨˜3n>õVbŸXõ^!ˆSv_Äl÷Â­:5Há6B�ðpÌE{ª ºŠ]Ï?çAoãRiÂsû›ŸO…Éèp³äêÖ÷9ÕF(�ÁœØ²›ÍXÎÝã°ï‘Jpó9£¾>c@u¦rö*��¸úa6Êå+çºzö„zTpM¥ÑÐ¼‘ÇÆßì¦Å,Ê=,ˆa˜u TÐfA™ØÀY›�ÛÒúçJŒµ¿3AœÏAqÏ€R›@~Î�ÁG‡v^à4ºFin*Jµb36vó¾ˆo@”™È°�Ø½’‡¶êRÐ’ËûLw™žV©«] #y<†7÷Âj”?L58«ûû8}ø6-0Ð,-ÅY–-Ë²ÿ!GµÖ.éÈõ¦:8IM4}©ñk÷÷—ŽqœÚÝJÕ¦â€ð`ñ¸ä\êy¦ôRÃB}gaìkYwJÑ]p
†^n>f®=MËE˜–t&^Vßÿ|òuáêÀ}!âÃ‹� F^‡ŠôuÞJ§Ò*{@(o`
ºŸ«z©->NbÜµÍg³ÖÔrAÖ²G“N°ÎÕ¦v3½Ó_ŸiËÂR^/LÒ£l	€]�™¥Ëø‘Å¡­–·Ó³?ª&Žð”ü¿Žë\ÞcÁÿzCP•U8t©­Ÿf>ëN3§œ±öa6sÕ;psàÅ-
}ë�L·þ-‚¸¥Û·ë;Ää|¿b¡;Fî^âãÔÅ�oCª1ŒAöÁ(QY+üD÷ÎLß¶´lUl;‚eY-´!ˆH*ÌÊ÷•<jðäïýÛÚ[¦g±æ‡—_‚¯ÌÊáÊøüµ«‚Üè]öÝúñI:¹è˜(ùý^­‰ÀÖ GcS*ÞÌÓowž¿BRÑÕþÛBŽ5‰ç£¼´‘Ázé'þÊÆ+úB²B'ÝV§S¤\³zà8d9îÚ—=-ˆVdÛóbR–ÅñVPPŽžK¼üõ�¼CÀ6c1§~ëd†Y*B�Šü€Û€˜dè°íÎ¹¡aDÑçíÁ— íŸ€m9ûâ©´9!ê¹Ûèü
©ýc”zü8üpÐGWÌ¶®gMš¾:SÞùà$ÿzwÐZ‰Gë�_sŽ\uáâÔ!æešÝBU d&ç©Ð{{zúq/ù¾©ýãŸ“sØšw Gô¨|‹ž½]¸Æ�Ÿ�1…3°ñ$[(�X	(;Ò†Nãu÷¿lˆ2¿Öºê¬ôJÏ×Ñ™ <¿j1.¿ï—6!˜ì`Æc‰BEÀQïék�Åö£ÀÜ:‘¿�¬zÔY2©Þ‘–^qüNVõ. H¡Ï™ówM/ÃµC[<¹³ò„­4ë &û{e¿AawˆÁóÍ‡’uç@«!LýÖ7YZšÙŒí¡ÊËAèÄ¦kQ]šŒ³÷SwÆ¶'¤™ZÇÐRœ ÈþBBt•YÊøªPR5Õ¡G¼*0ýÍ*Ã¤á æ±$ûÆ#ö™#¡eŠoFn zylÀnLli‰©ÙÅ!í‰¹1_V8«Ê T@”•Ö€@ó²ÑœÐ¾‡
)ÍþÈ¨ŠŸDdïÁ$,5tÃàz›ç‡ðËçWˆ’Y•·©
ˆV3Êf=E¢å›ü°†<¦³¤Ÿ�žì´L¸¦�Ÿj{Ÿ|Í9V]ËyUÚŒêÅ+þõ8º‡i¯°l·êµ¹×¾V+ÄÒÃSfÒN²¦Ë[ÅÙ^jpÏÙö¦T*&ðK3 ‘u¾¹rj7�¯‰w|¿3¡ƒØ¤Á+Ã›£ªŽ¤vx!P„|Õa4á5H[�ŒŒ³]ÅA§N‰'§WÏ»ú!XÁi¸xÆôø¿Û^àI³¨Á»=¾áñÎîÊ°PAü|ÎU•á‰ª¼�bgÝJ“ÄûÔÜ¹™@ö*¹ãU¥b°�I­wéf;ìmˆ‡I(÷J‚ãc	ù;(„»ËØ!3ËÏ!ü}ÎŠÜà,æHÌ¼\ÜÄÏÛ§Ä¾Æl�íPñÒËU£÷;÷­D D $º ö§2á �œ@  ±äÏ4±Ägû    YZ  a      _  4         47»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÞKÒ �k�½7H0ó±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  M<?xml version="1.0"?><Features nextValidID="13"><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5260-5364" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3071-3192" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1887-2022" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="995-1219" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1707-2036" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1265-1693" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3643-4228" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="G418" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2103-2897" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5190" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4399-5190" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5191-5259" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="862-969" color="#ccffcc" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>c84247ce-c15a-47e7-ae36-0b174ccf4021</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="5:54:35">2020.9.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></BottomStrand></StrandColors>  &      ®ZTR

BASE      5  xÁA  ƒ°YëñÀ þµ,9³±E¹Y³6a¶H’2³t’³™ˆ“m«6illÊ¦”ÇV²ÜÜ"©©5Å*‘¤—æZC,ÇÊÕÊÑ¬ÕÖl‹­†j¬f±&°ÖÒY ÖX5´m) ¤ä@`Ã °r[[[°fÂÖÔQÁÊal©élÕÐ¶‘À(e6›Ùb-a³! ­Æ–CÛ–BÊj	ÌÆrPK4J™�EÃV3Òj°4—h•2‹-Ó5ÑÊCulF0€•ÃØRge•2Ø¶ØPGÛ–a� +‡lKE›b64u­µÉœD¤´Ñœ0’)µp[mGŒÖÔ9`“”&VÛ¨MJ8	]0šÁÌ4ÝŠd®“1S$œÑœ
Xm$Â‘	E³„	‹,+À„‚r@ºiÂTÐÖ¶åt[ÉBVFÎ¦+Z‘ª¦š*Ó1ÙT�®ÔÍ±5™²$Õ%šJ´”"§è67˜¤J4U[ C²‰"«MDQ3MkˆLÌ�4F	�&THE!A© ŒM¢m¡*ÕÔWÍ¤Ê À¶m”«©¹´6Sa!�k­
�Êaé†Eµ5ÓeÁ6Ò��Ð"4ZQåªµ©«\…B+­mÛr’«6¶mÕ†¸ÕVdºefÌššé6˜ÀdÊÜlÉ6Y²ˆ­fL6˜fºÍ ¦0™27[²M–,b«“Ö �@`´Ì�� KÉÑVUµjÉœ‚S"!rÒ
æf3§SªJ§Ð”*Ù¶I€:)[V….r±9Çt9]X!Ë•›KW2dZ
Rj:§´Bi9Rsl¡$‘KÌ%c"SE@‹ªŒÍ�ƒ4�Ür#™§LDiaJ
Ã¡bA‰L2	‡eŒÜDÝÔ‘’´Rq3A•é"ÈXÄ $Hpn³‹¥ä’-Q”d)(Xá`°‰ÛXÈÂ‰“a#té&h”ábº\¤ÃÍÉbª„ÜÈB˜›"²ŠÓEæ€¥¸„¤·KÓmKAªHW,™‚’š):�Ó±&–Ò s­$7'¥(n©ä@
Â¤ÚB� WÈDBÑB(Êá,Šœ¨#R-Ü–›86HXç*\Á@Š–Û´T
ÝÂ*P‡ ¤ËÁDT±$�E!0€�²ZÉ¤Ö–ÖØÖ6Ùš,Æ¶Š±­m²ªŠ‘¬h–ie°�XlÙ¢ËÈÖÀpMš“Rl‹¥±&YAfn+k�ÄØ
ÆØXÃ	ºÉÚf¶MH5¡-gNÚˆ±ÚJ,‘	H3Ôm�aÂ$Ym¹…Â†ˆêœ¢•ØJE¢@
BbäI$4,”Dq¢-&1b›¢m­cn1Õµ!Ómn,s²m
“mS˜n`Û6±$Åª`M	€NcÛ‰Í˜Ó·Žéhms¦X�n&A8 Aj k��PP¨›˜"±&1$›¶ˆYh6	6I%3n `1’µ@Ûha”3Ø msG-„‘2™0Ò6¦«Éœ8mÙMsåfšB¥1š›³UÚ"‘Hrf
Ý¶9K›D¹@ÙÆ6HÚD«*+Ùd2WCdnÛ6]Äææ‚ÊEÕÈ!1Ó·�Ö¦®Jc9W‹m›.ŠAsAÕ¶Ú¶åfÕ¶Ø¢m¶Ör¶�ÒÈ1k°%µÅÌ)ƒ1q‘Ñ*,¬YBŽ ³¹6®¡N¥‹`&É–k ÎCb sÕb²µ&LÐM'27Ó Ù¨Á‚­¶²u“æl³Y³¶f%²aYÂJS¦CÂ°Ò–R¬˜ZÀ†‹MqÖX. –e²m›hM‚BƒÀ…eÌÍ6KAfÖbÄÒZÊd$k+¢FÆØæ’*2Gš³lÆŠœ[3[¢8p–D	(ÆÖP×Ö@„±&s£Ú6“X¬tÛ°(TqÛˆØtQÉr.˜…Ë6`„É€�\“EÕ¨L¬HÍÉ¶�é¦l[‚lÛ¦nm*Ž¡Û²Ü±FTÅÖjå&«SkeÄr¢k¬UnÙª¹mkÛšj�ÈXà¶™0Èa8t¡ÎE€ ¥=G}ôn  Àý7zXZ  æÖ´F !   t/å£à*¿€] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÉ;_x�ïÕxíO	¤ÜQ…ÙÑšÆä‘—`wTo•C<SÜ—ÿ7HJ¸«ˆ™]÷Õ„ð ÁæÃ_éÉå	"%ÖÒMþ<^¿©¿Öm¼ MS9,†Èx}ÿž«8Ûš8‹>ÿøÁ’�-nÖå„Á½`›[µ5ï<cïËªeçÀ#_µ0_|#W˜ÔæðÎô…eýJ!X†Èö¸d >"ˆÇ�²»n§í+hu£Ùñhö6µ:êå~täœÀ/<»6%
[×aÉ»ªÖK¹‘g©C¼ñG±Ù8Œ0	É×~›¥N³$�¾‹7¾—Ø½’ÚæØ5®Uí�?£/Í°—Ú´¢xÉ“dlŠHy ”??H_l©ëËÿ´ÓÍ9±„w}õ]“Å{un–vÆ‹Mûœk„Gèy¹R¥Ö }Ì±L@]µÞÚÝ�>¬zø¯î6,æŸ/‡iÉ‘	8æŒVá•z÷ ¨�E²�‘}ýøBåäÝ7ÂètUÏ­ñÍ…ãQâkèf1â”x‚²3N4…öasôÌy.± @ð“�Q©1ÿ²^øHÿ+¨ùóÛŽa·¼.ÌŸÔÓù(Ë)R[Uö¹MÁk[-!@¾’–¶4$–D4D@.±B»ØpÙWÆ%²ä…á‚–-Ž}`SbålÛ7N&£µ·¥ø·�—‘/$æ#"·cÚ’B7Ü5IÆât1ÅËÅ¸(ÿS=³oü–è‹	Í;K“€ÏÁ	>èÆˆ,4§±�ÆørJlõý¸j’ÆÆœú�’8^jŽaQÙSH�Eý%?…ÿNÉ‡Xä“g5!È,
i�±áëx®ã±V90Q¦iÝÙŒç ½�L]ö*Ñ¬:ê(yQ”zYš«
*^Ä9ó�Ž¬ªj]d?Ón©$™Õ*"K»ðO‘Ew Ïïvè@'ªýfê,«(M¿ùiÀì }Y5}Z'ÿ¾îj–h˜ƒ¦çÜZÀ¬–%C½.áÅo¹)¿ÆXO*ß@çëžìÕ„&n’6änìÊ¶FÔ{ÁWn¿RÓ°s”¼.68d¨þsFÆ(„¹sú�Cäò©éÔ8ð¿ÇëøUëßÉm5ZËu}V1Aˆ¢­ýï¾
$²?MŠ{÷-‹ÈÊm=5|ËœV­¨(è8°äÕj'0k‹}¶õ÷áŸ™XæxM1Êjµ¸„ñäæ_º¢»<ºd)§rc%úö3²S‘lO	Š5KÎÄÝÐú6”F;7VÚY\|_[ì´ÌoñÆqøz¸²«œpÅüúœýbC08Žº†5½¬LXÞ·r÷ûEÁ‘}ìVÞ²¾å¯ñSÚžS”Åí’¢ãæP]n�_Ò/aÚâ˜+ËÜy¹4PqpòS}y’ö»#Õ»}½~[Ëµð±±Ô‹pØq1lÁçX­„Â>yÛˆMï�ÅIþ‡–jãMÌšZ‰m¥gÏ
|JhìIÃ+rV|‡° ñE¤}ê  e‚Ïïäwèøw ©¤PuT.ÿz1Þð@†Ð¯!jù+èýmcBÑÅÔ—ºnÌ…�-þid…5ÓN|¸LÒâª8‚£…X½žÅK7ç*B'i,ß:%ÔðÊP!³Å€Ó\*!/ñµäÆœUà ²�é'õÈ}`œ®çqÉqKw@` ­ŽY#:‚¨jÏ0åÓ®È÷ÌWW°»}\‰‡kÓá²R%}÷A=ÆöZJìÅ+«	«9 Ö`%Ò»²^:*•ºMÀ;i7úîè›^u×²�8�ú^ng3Cœt $U…áab¥$¿W^oúÄ|:È`ôWŽ¶ÆŸó#F—‰ž«ìžó÷Ó@�M±h+’œ¨×ó6Ö†aS«Sá6^�Œ1É°°ßÖé¾Fì9wmmÖWŽcÐëáSPãQLk·.Cž5
®8‚‰�Î²dÒ[€	Üz¡Ø€0d¡ÎÅ¡¤SøÚ†qX|n,*-hO{šãN�œLî|³Ê÷â¶í`ŒA¹Ùñö–]òY�„Ø­£‹�?+ùüñìŽc¢'V¼Ü*òg:*ï{›;OAÈ[Ó–Í%¬ÿ‚­èõã”Îðü„-©�˜=QbÛÓé…+‰wÙžy˜â/JëOÐ¨üÒÔZòZŒ× ·Ý-8oI±Û€ÛSãÞ%GsZ;xfö€kl@JïãNÊ!	$é%*¨–^¦7‡‰Ý`cYÊU§ä/í8ú×¡ø}dY€be5ËðJªK›âå@
ŸEžÔíûR–�í¦,–O¢†I�ÙáK)*…¾9”ÉÇ‰§µ¹é¼æ¢#^ÿ"™Ì“¯ÔS(â¥ ›6Û#$¥$Óðl�¼~v Í+æ½ŸØýîÝúÑsw`ð•ÝÙWû¸êà†)åÚŠZÇ‰l-ñyªë*ùqŒ¹-OyÉuÕ³Ñ³ÀÏ-§b   ¹¸'¼EÐÙ œÀU  i—›7±Ägû    YZ   ‹<AlignableSequences trimStringency="Medium"><Sequence name="pCDNA3.1(+)" ID="0" sortOrder="0" trimmedRange="0..5427"/></AlignableSequences>  Þ‹     ÿ BC N srôe”```pðpáó³2Ô3ãö·²*Í+Î/*IMábÊqqQjZjQj^r*ÃiQ /ã6   ‹     ÿ BC rí–1Î|;Å(hhÉ%‰‚”’'QÐÆrvó¶Ë…WAÁF¿üyzk¾™ûÝÉäÚÇççOùü¿ÿåŸõ�|þýÏŸÿ‰¿}~þÇçó»?|>ÿþ;ŸÏO?±ú¯ŸÏÏÿú|´º·Ûe©‡èì÷Ü6ÚõXcižsb›k´{T·–’·­ZzÓb+ê¬%Uv+¬¿v®ÍLÕX®;î´ÑDªž¨rs¯–r¥]éÂ—§gË~uˆˆµzn¿5«Ý:tÙÚCG™uð!QO—Â»ìQµK³šÞsO/a±�üøñÒQÓú©Ò[\ÑÞîcýw�=Os„Ê�ñÖí‘b{å¸+0üÎ›Íe.¹C\,ÝQL�I›‡jú´Íó›{¿&hûäÉÐÚ‹ôúcÏRÂOéÕç�EÊÃÕ 
|Ž�í½·õ­î¡·Þ½ë¨`Iõ×wÉrgõz¯í=zãn›I‰4!N�mÍí}5ïç €xô}½km¡6Ô÷Y­Q+?smoÃ÷:ºüžmÈ:‘1†�ñnÒÏ»íkôuFú*·È¶"Ñ]%X¸øÍefaÇ¬[m½™µ�¶[-W›Š†í <õškÛÜe×Îmî˜£ªŽ¸j³gQ>,âXr·MhµjMí,¹ü©¯œ+—�$'×>sÚq€d™f°5›åØ	QóN­âôRjn¾±ìó’…Œ�Vé(WI× Î¨ÇfÆ^+hY�ÇW¯ãºÛ+7CR
ýN�’S!Ó¹p”/Jº¨ºa·}@61Ð”Ò|t²­[ßíF/À#œ®e´ÿc�ð½ŽUÖÓÄ÷‘©Ÿ÷–ïf�z%3oòëmƒ—®ÅkëÍÑÊiÑ6�%j—žQÔ‡m4.2$Ý‚”½»Ñq™ #;�aÇN­ÚŽûÔ¹žÐØIœ¿½LÁiw™h~í:�Ïik3Zg —t	£€PcmÙ5 Í6Ö°Ç$w:ZÑœp$èÜ	¯QFYehÛ,G§iÛîìï^cï�äA Zb²§â9¹Éöò}ÏYû(ºË£ðl³ÁdÑ‡yž)¯`�=ËV®mÍ‰4H’5õbsö$8ß£ìÄ¦(î¨³à/ òEQ¦Q#< ´LfÏŠa¤­:Î¾©ÁƒÒ&l1}T÷5c=çràS	�+"}o¸[ƒúÑ¦UGq˜Â³ÝÞfÅ)Púl0R0!�#éJ±4Í¹i"ÍØO+¯Ä5ÚÄ±Ü‘ç†ï°gŒßÉ©­{‘H-R¾Ú�«ìùë£UÓç�»¡Ç�`PrÖ‘:}¿z”…¹ÇÁÕ÷8;×çê�üz¯R·ÎÝú-ç”6¨GW	È	»;N�VcáŠ³žiÞL¼Š®P‘v,·iXràÒ�Ì9\aLeRÍ5Áó
PÛuºx°Rré}¿.K™á•ÑzixM)Œ«]ç}¤±Þ,óŽXP¼�?PÁl*¤8ˆ,à¼h{šÔÎzŒ^áE“4`'~Ä�ë“' ÅÅÆrhí©Ð…ìæ:4Ñ³Å5?Tòœ!DŸeàrøö„(ª@NˆZÐˆÁ?í¤L††¶ŽsÛ%£|eÛe¿yôö×îÝ0X¬o¼Œü¸Ý‚±PCËJj¥´–vAõ)¨Ô‚z4Î›x(9µð˜ýÃ§KaSÙMðQYéo¨¥X™…ŽÎüa™æ²w
–ƒÉ Ü÷ƒ,ÒQ³É‹CŽûà×æQÉ¥‹fq¨�•ƒŽ¢QŒxP{K]Ã„w¿’„YçkgŠâŒÌù;ôMÒA œDH@!4âFùÅ/è”½&ÀïPŽ‘/�²­@èƒq>`Sº–™ÌM‰U™q30yÈæ¸˜r=»ÒçÄÂÁC7§™`ÎõÈ·ð²„9Ïð‰0Ï3z€Ú‚Ä¢¹¯ƒð¼äbþLGýÅ˜)5Î>ÕË€zÔÍ¬º�ácÃÔ…?)§@¸È2 áMQ¥Åê.Ôp¸'tŒ. Näæð€¡ÄåÌáG+n°�2èå]ÙñmO ±gˆtÝÊm6kå`p¢ÜÕïÂÅ°	y§¼ÖA“YÌy�¾+ÌIf¢$”Å¹�Ù5Ñ»hÂyc0†qXy“g�Œ¸8¿|ãßøÆ7¾ñ�o|ãßøÆ7¾ñ�o|ãßøÆ7~‹ÿ ²�Ò¾   ‹     ÿ BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  Ž<?xml version="1.0"?><Features nextValidID="13"><Feature recentID="0" name="PuroR" directionality="1" translationMW="21496.48" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2449-3048" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="1" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5411-5515" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3222-3343" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2233-2368" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1341-1565" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2053-2382" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1611-2039" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3794-4379" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5341" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4550-5341" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5342-5410" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="12" name="Mir301" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="902-1297" color="#a6acb3" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  §<Notes>
<UUID>d8c5db18-7216-4b4d-9805-e877406de6d7</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-Mir301(mouse)-SV40-Puro</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="12:30:6">2026.3.26</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             Ç<StrandColors><TopStrand><ColorRange range="0..1980" colors="black"/><ColorRange range="1981..1982" colors="magenta"/><ColorRange range="1983..2447" colors="black"/><ColorRange range="3048..5578" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1980" colors="black"/><ColorRange range="1981..1982" colors="magenta"/><ColorRange range="1983..2447" colors="black"/><ColorRange range="3048..5578" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
